Journal: Journal of Imaging

Article Title: Ultraviolet Fluorescence Photography—Choosing the Correct Filters for Imaging

doi: 10.3390/jimaging8060162

Figure Lengend Snippet: Fluorescence of the test photographic filters normalized to Schott KV-418. Bar color indicates the color of the filter fluorescence.

Article Snippet: The Schott KV-418 filter shows a gradual cutoff starting at about 405 nm ( a) and then rising through 50% maximum transmission at approximately 418 nm as expected.

Techniques: Fluorescence

Journal: Journal of Imaging

Article Title: Ultraviolet Fluorescence Photography—Choosing the Correct Filters for Imaging

doi: 10.3390/jimaging8060162

Figure Lengend Snippet: Optical transmission spectra of the test filters: ( a ) Firecrest UV400, Schott KV-418, Zeiss T* UV and KS 420 nm LP from 375 nm to 450 nm; ( b ) Firecrest UV400, Schott KV-418, Zeiss T* UV and KS 420 nm LP extended range from 350 nm to 800 nm; ( c ) Schott GG400 and GG420 from 375 nm to 450 nm; ( d ) Schott GG400 and GG420 from 350 nm to 800 nm; ( e ) Heliopan Yellow 5, Hoya Yellow Y(K2), Tiffen Yellow 8, Tiffen Yellow 12 (version 1 and 2) from 300 nm to 600 nm; ( f ) B + W 486 UV/IR cut and Baader UV/IR cut from 300 nm to 800 nm; ( g ) Schott RG665, RG715 and RG780 from 600 nm to 800 nm; ( h ) Quaser 415 nm 1%, 476 nm 1%, 510 nm 1%, 549 nm 1%, 593 nm 1% from 300 nm to 700 nm.

Article Snippet: The Schott KV-418 filter shows a gradual cutoff starting at about 405 nm ( a) and then rising through 50% maximum transmission at approximately 418 nm as expected.

Techniques: Transmission Assay

Journal: Antimicrobial Agents and Chemotherapy

Article Title: A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

doi: 10.1128/AAC.02588-18

Figure Lengend Snippet: DSTA4637S mechanism for killing intracellular S. aureus. Step 1, DSTA4637S binds S. aureus. Step 2, host cells internalize DSTA4637S-bound S. aureus. Step 3, fusion occurs with the phagolysosome where lysosomal cathepsins cleave the VC linker, releasing dmDNA31. Step 4, unconjugated dmDNA31 kills the intracellular bacteria.

Article Snippet: The observed unconjugated dmDNA31 mean maximum plasma concentration was 3.86 ng/ml at 150 mg/kg of DSTA4637S, of which approximately 95% is expected to be plasma protein bound (Genentech, Inc., unpublished data).

Techniques: Bacteria

Journal: Antimicrobial Agents and Chemotherapy

Article Title: A Phase 1, Randomized, Single-Ascending-Dose Study To Investigate the Safety, Tolerability, and Pharmacokinetics of DSTA4637S, an Anti- Staphylococcus aureus Thiomab Antibody-Antibiotic Conjugate, in Healthy Volunteers

doi: 10.1128/AAC.02588-18

Figure Lengend Snippet: Mean plasma or serum concentration-time profiles of DSTA4637S analytes. (A) DSTA4637S conjugate, LLOQ = 9.46 ng/ml. (B) DSTA4637S total antibody, LLOQ = 50 ng/ml. (C) Unconjugated dmDNA31, LLOQ = 0.185 ng/ml. No mean values for the 5-mg/kg cohort were calculated and plotted in panel C because more than one-third of the values were below the limit of quantification at any time point. Error bars indicate standard deviation (SD). Dashed lines indicate lower limit of quantification (LLOQ).

Article Snippet: The observed unconjugated dmDNA31 mean maximum plasma concentration was 3.86 ng/ml at 150 mg/kg of DSTA4637S, of which approximately 95% is expected to be plasma protein bound (Genentech, Inc., unpublished data).

Techniques: Clinical Proteomics, Concentration Assay, Standard Deviation